Prof. Dr. 

Rolf Backofen

Department of Computer Science, Faculty of Engineering, University of Freiburg
Georges-Köhler-Allee 106, 79110 Freiburg


Selected Publications

Antony D, Gulec EY, Gezdirici A, Slagter L, Bakey Z, Bornaun H, Tanıdır İC, Van Dinh T, Brunner HG, Walentek P, Arnold JS, Backofen R, and Schmidts M. Spectrum of genetic variants in a cohort of 37 laterality defect cases. Frontiers in Genetics 2022;13:861236.

Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, and Beisel CL. Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA. Nature Microbiology 2022;7:530–541.

Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, Agüero MG de, Szalay A, Lämmermann T, Macpherson AJ, Ganal-Vonarburg SC, Backofen R, Erny D, Prinz M, and Blank T. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine. Nature Neuroscience 2022;25:295–305.

Wandera KG, Alkhnbashi OS, Bassett HVI, Mitrofanov A, Hauns S, Migur A, Backofen R, and Beisel CL. Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases. Molecular Cell 2022;82:2714–2726.e4.

Mitrofanov A, Alkhnbashi OS, Shmakov SA, Makarova KS, Koonin EV, and Backofen R. CRISPRidentify: Identification of CRISPR arrays using machine learning approach. Nucleic Acids Research 2021;49:e20.

Uhl M, Tran VD, Heyl F, and Backofen R. RNAProt: An efficient and feature-rich RNA binding protein binding site predictor. Gigascience 2021;10.

Makarova KS, Wolf YI, Iranzo J, […], Backofen R, et al. Evolutionary classification of CRISPR-Cas systems: A burst of class 2 and derived variants. Nature Reviews. Microbiology 2020;18:67–83.

Padilha VA, Alkhnbashi OS, Shah SA, Carvalho ACPLF de, and Backofen R. CRISPRcasIdentifier: Machine learning for accurate identification and classification of CRISPR-Cas systems. Gigascience 2020;9.

Costa F, Grün D, and Backofen R. GraphDDP: A graph-embedding approach to detect differentiation pathways in single-cell-data using prior class knowledge. Nature Communications 2018;9:3685.

Aktaş T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, Manke T, Backofen R, and Akhtar A. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature 2017;544:115–119.

Administrative Manager

Marc Schumacher

Institute of Medical Biometry and Statistics,
Faculty of Medicine and Medical Center –
University of Freiburg