Cheng Y, Schlosser P, Hertel J, Sekula P, Oefner PJ, Spiekerkoetter U, Mielke J, Freitag DF, Schmidts M, Kronenberg F, Eckardt KU, Thiele I, Li Y, and Köttgen A. Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism. Nature Communications 2021;12:964.
Schlosser P, Li Y, Sekula P, […], and Köttgen A. Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans. Nature Genetics 2020;52:167–176.
Teumer A, Li Y, Ghasemi S, […], and Köttgen A. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nature Communications 2019;10:4130.
Tin A, Marten J, Halperin Kuhns VL, […], and Köttgen A. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics 2019;51:1459–1474.
Wuttke M, Li Y, Li M, […], Köttgen A, and Pattaro C. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics 2019;51:957–972.
Tin A, Li Y, Brody JA, […], and Köttgen A. Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels. Nature Communications 2018;9:4228.
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O’Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RPS, Brown MJ, Gaffo AL, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics 2013;45:145–154.
Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, Angelis MH de, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature 2011;477:54–60.
Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O’Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, et al. New loci associated with kidney function and chronic kidney disease. Nature Genetics 2010;42:376–384.
Köttgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, Smith AV, Arking DE, Astor BC, Boerwinkle E, Ehret GB, Ruczinski I, Scharpf RB, Ida Chen YD, Boer IH de, Haritunians T, et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nature Genetics 2009;41:712–717.
Institute of Medical Biometry and Statistics,
Faculty of Medicine and Medical Center –
University of Freiburg