The British Journal of Dermatology (BJD) has published a research article authored by our PIs Cristina Has, Moritz Hess and Harald Binder, together with our doctoral researcher Hanning Yang, and our postdoctoral researcher, Meropi Karakioulaki.
The study titled “Systemic inflammation in recessive dystrophic epidermolysis bullosa: a five-year longitudinal study” is the first to map longitudinal trajectories of systemic inflammation markers and their clinical associations in recessive dystrophic epidermolysis bullosa (RDEB).
“RDEB is a rare genodermatosis caused by mutations in the COL7A1 gene, which encodes the alpha-1 chain of collagen VII […] These mutations compromise the attachment between the epidermis and dermis, resulting in skin and mucosal fragility. Minor mechanical trauma can lead to blisters and wounds that are accompanied by systemic inflammation. “
By characterizing how systemic inflammation evolves over time and relates to clinical outcomes, this work may help identify which patients benefit most from specific therapies and inform optimal timing of interventions.
Learn more about the study and its findings here.
Institute of Medical Biometry and Statistics,
Faculty of Medicine and Medical Center –
University of Freiburg
